8/28/2023 0 Comments Composition of transformations![]() ![]() ![]() In the study, researchers looked at blood samples of seven centenarians. Intrigued by centenarians' exceptional resilience and ability to ward off aging-related diseases, scientists embarked on a visionary study to unravel the secrets of their elite immunity. This breakthrough opens up new avenues of exploration in the realm of healthy aging. Recent research has revealed a remarkable discovery: centenarians possess unique immune system composition and activity that contribute to their extended lifespan. Understanding these changes is crucial in the quest to understand longevity. While immunosenescence leads to a decline in immune function, inflammaging fuels a chronic state of inflammation that further impacts health. This persistent state of inflammation is associated with increased levels of pro-inflammatory markers in the bloodstream and tissues, contributing to the development and progression of age-related diseases. However, with advancing age, there’s a subtle shift towards chronic, low-grade inflammation, which characterizes inflammaging. Inflammation is a normal immune response, protecting the body from harmful pathogens and other stimuli. The second change is known as inflammaging. Genetics, lifestyle choices, chronic diseases, and environmental exposures all shape the trajectory of immune aging. There are significant differences in the extent and pace of immunosenescence among individuals. As a result, older people often have compromised immune function, making them more susceptible to infections, autoimmune diseases, and certain cancers. The composition and function of the immune system gradually change over time due to alterations in immune cell production, changes in signaling molecules, and decreases in immune responses. The first change is the phenomenon of immunosenescence - the age-related process of immune dysfunction. The immune system is critical for health and survival, and with age, it undergoes two significant changes. The dynamics of aging and the immune systemĪging is a complex journey that triggers numerous transformations within the body. ![]() These findings provide a foundation to explore the factors driving extreme old age and could lead to the discovery of healthy aging therapeutics that protect health and extend lifespans. ![]()
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